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The escalating global crisis of antimicrobial resistance (AMR) necessitates the urgent exploration of novel bioactive compounds from untapped marine ecosystems. Seaweed-associated (epiphytic) bacteria represent a promising but understudied reservoir of chemically prolific microorganisms. This study aimed to isolate, characterize, and evaluate the pharmacological potential of bacteria associated with the green macroalga Chaetomorpha linum, collected from the Manapaadu coast, India. A total of ten bacterial isolates were recovered, with strain MG51 exhibiting the most potent antagonistic activity. Molecular identification via 16s rRNA sequencing confirmed the isolate as Providencia rettgeri strain PMRU2.3 (GenBank Accession: ON604798.1). Chemical profiling of the ethylacetate extract using Fourier Transform Infrared Spectroscopy (FT-IR) and Gas Chromatography-Mass Spectrometry (GC-MS) revealed diverse functional groups and sixteen bioactive compounds. The dominant metabolite was Propanamide, 2-hydroxy- (42.13%), a predicted proteasome inhibitor .The crude extract demonstrated significant broad-spectrum antibacterial activity, particularly against Gram-negative pathogens, showing maximum inhibition against Pseudomonas aeruginosa (79.0%) and Klebsiella pneumoniae (71.3%). Unlike typical clinical isolates, strain PMRU2.3 was susceptible to standard antibiotics, suggesting it is a non-virulent environmental lineage. Biosafety assessment using the Brine Shrimp Lethality Assay indicated significant bioactivity with an LC50 of 639.28 µg/L. This study reports the first evidence of antibacterial metabolite production by P. rettgeri isolated from the phycosphere of C. linum. The presence of potent bioactive compounds suggests that this marine epiphyte is a viable candidate for bioprospecting novel pharmaceutical agents to combat multidrug-resistant infections.

Unig Journals introduces Unig Science, an international, peer-reviewed, multidisciplinary journal dedicated to all fields of Science and Technology. The launch of Unig Science is not merely the introduction of a new publication, it is the establishment of the premier, author-centric scholarly ecosystem aimed at fundamentally changing the traditional publishing landscape. Published online by Unig Journals, Unig Science publishes impactful research papers and reviews across any area of Science and Technology. Our comprehensive scope is strategically divided into five major divisions to ensure broad coverage and we welcome high-impact research papers and reviews across all of them: 1. Life Sciences, Biotechnology & Medicine Covering areas like Ecology and Biodiversity, Molecular Biology and Genetics (Genomics, Proteomics, Gene Editing), Cell Biology and Physiology, Medicine and Health Sciences (Oncology, Immunology) and Agricultural and Food Sciences. 2. Physical Sciences, Mathematics & Data Science Including disciplines such as Chemistry (Organic, Physical, Theoretical), Physics (Condensed Matter, Astrophysics, Materials Science), Pure and Applied Mathematics and Data Science (Machine Learning Theory, Predictive Modelling). 3. Engineering & Technology Encompassing Electrical and Electronic Engineering (Robotics, Telecommunications), Mechanical and Civil Engineering (Renewable Energy Systems), Biomedical Engineering and Computer Science and IT (Artificial Intelligence (AI), Cybersecurity). 4. Earth Sciences & Green Energy Focused on Environmental Science and Sustainability (Climate Change, Waste Management), Geosciences (Geology, Oceanography) and Energy Research (Solar, Wind and Energy Storage Technologies). 5. Interdisciplinary and Cross-Cutting Studies Addressing vital cross-disciplinary fields like Nanotechnology and Nanoscience, Computational Modeling and Simulation, Science Policy and Ethics and Technological Innovation and Entrepreneurship. This inclusive philosophy ensures that Unig Science is a platform featuring insights from the entire range of diverse experimental and theoretical approaches being applied to solve the world's most complex challenges. Unig Science is dedicated to revolutionizing this landscape by creating a sustainable, author-centric scholarly ecosystem. Our innovative Publish and Earn (PAE) Model is a deliberate strategy to break the traditional profit model, transforming the author-journal relationship into a genuine partnership. We are committed to making Unig Science a success. We encourage you to submit your articles and join this revolution now.